Mannitol spheres are a unique form of spheres that are made from sugar alcohol called mannitol. These are commonly used as a sweetener and in pharmaceuticals due to their non-toxic and non-allergenic properties. The spheres can be loaded with various drugs and can be used to release the drug at a specific rate.
Mannitol is classified as a polyol and is an isomer of sorbitol. This means that it has the same chemical formula as sorbitol, but a slightly different molecular structure. As a polyol, Mannitol has a variety of uses in the food, pharmaceutical, and chemical industries due to its unique properties.
What are Mannitol Spheres?
Mannitol Sphere is actually 100% sugar-free and easily soluble in water. This is why they are an excellent substitute for sugar spheres for layering and coating medicines/drugs.
Mannitol spheres are tiny, spherical particles made from mannitol. They are typically between 100 and 500 microns in size, making them small enough to be swallowed as a pill. The spheres can be loaded with a variety of drugs. They are designed to release the drug in a controlled manner.
How are Mannitol Spheres Made?
The inert and non-hygroscopic mannitol spheres are an excellent starting point for layering and coating controlled-release formulations. Composed of 100% Mannitol (Ph. Eur/USP-NF), these spheres are perfectly spherical and made using a proprietary spheronization process that allows for precise control over their density, surface texture, and particle size distribution.
Thanks to their high mechanical strength, low attrition, and optimal particle size distribution, these spheres are ideal starter cores. They can be used in various pharmaceutical grades, including microcrystalline cellulose, cellulose pellets, hydroxypropylmethylcellulose, sugar spheres, sodium starch glycolate, croscarmellose sodium, and PVP.
Features of Mannitol spheres
Mannitol spheres possess the following characteristics:
- They are prepared to facilitate rapid drug layering.
- The drug layering on these spheres is uniform throughout.
- Mannitol spheres have an ideal spherical shape.
Applications of Mannitol in Food, Pharmaceutical, Chemical, and Medical Industries
Mannitol, a naturally occurring polyol or alditol found in many plants and microorganisms, is widely used in the food industry as a functional sweetener due to its favorable physiological effects.
Apart from the food sector, mannitol has a wide range of applications in the pharmaceutical, chemical, and medical industries due to its advantageous properties. The production of mannitol can be achieved through extraction, chemical synthesis, or fermentation, and various mutants have been created for different purposes.
Benefits of Mannitol Spheres:
There are several benefits to using mannitol spheres in the pharmaceutical industry, such as :
- Manufacturing Dedicated Pharmaceutical Grade Products
Mannitol spheres are made with a proprietary spheronization process that allows for precise control over their density, surface texture, and particle size distribution. This ensures that the spheres are of high quality, making them an ideal starting point for the layering and coating of controlled-release formulations in the pharmaceutical industry.
- Total Compliance with EP, USP, IP
Mannitol spheres are 100% compliant with the European Pharmacopoeia (EP), United States Pharmacopeia (USP), and Indian Pharmacopoeia (IP) standards. This ensures that they meet the quality standards set forth by these regulatory bodies, making them a reliable and safe product for use in the pharmaceutical industry.
- Outstanding Microbiological Quality
Mannitol spheres have excellent microbiological quality, thanks to the stringent manufacturing process they undergo. They are manufactured in a controlled environment that ensures that they are free of microbial contamination, making them safe for use in the pharmaceutical industry.
- Customized Size
Mannitol spheres can be customized to meet the specific needs of different pharmaceutical applications. They can be produced in a wide range of sizes, densities, and particle size distributions, making them versatile products for use in the pharmaceutical industry.
Mannitol spheres are widely accepted by pharmaceutical manufacturers worldwide. They have been used in many industries and are a proven and reliable product for the layering and coating of controlled-release formulations.
MB Sugars: A Reliable Manufacturer of High-Quality Mannitol Spheres
MB Sugars is a leading manufacturer as well as supplier and exporter of the highest quality Mannitol spheres around the world. They manufacture unique and versatile mannitol spheres that have found wide acceptance in the pharmaceutical industry. Due to their non-toxic and non-allergenic properties, they are an ideal starting point for the layering and coating of various formulations to meet the specific requirements of different pharmaceutical applications. Mannitol Spheres developed by MB Sugars conform to the quality standards and excellent microbiological quality, making them a reliable and safe product for use in the pharmaceutical industry. For bulk supplies and export quality Mannitol Spheres, MB Sugars is a trusted name in the global pharmaceutical industry.
